Aapptec Apex 396HT Automated Multiple Peptide Synthesizer

Apex 396HT Automated Multiple Peptide Synthesizer

The Apex 396HT Peptide Library Synthesizer is the ideal peptide instrument for drug discovery, SAR studies, receptor binding studies and other applications utilizing high throughput screening of peptide libraries. The Apex 396HT automatically prepares and cleaves peptide libraries into standard 96 well titer plates ready for concentration and screening.

The Apex 396HT Peptide Library Synthesizer can prepare up to 192 peptides and cleave them into standard 1 mL-well titer plates with approximately 0.05 mmol of crude peptide in each well. The Apex 396HT can prepare larger quantities of peptides by utilizing AAPPTec Classic Reactor assemblies.

The Apex 396HT is based upon the very popular and reliable Apex 396. Like the Apex 396, the Apex 396HT utilizes robotic probes to deliver amino acid solutions and reagents with syringe-like accuracy and precision anywhere on the instrument work top.

The Apex 396HT Peptide Library Synthesizer features:

  • two bottom-frit 96 well titer plate reactors
  • two standard 36 vessel amino acid racks
  • four 750 mL reagent bottles
  • self-contained enclosed work space
  • flexible, easy-to-use software

The Apex 396HT Peptide Library Synthesizer multiplies chemists’ productivity. It can prepare an entire library of peptides in the time it would take to synthesize one peptide manually. Plus, the Apex 396HT can operate automatically overnight or over the weekend without user intervention, further increasing productivity.

The Apex 396HT Peptide Library Synthesizer is the best peptide instrument for preparing libraries for high throughput screening.

Product Specifications

Light Source 50 mW diode pumped solid state (DPSS) single-longitudinal-mode laser
Laser Wavelength 532 nm, other wavelengths available upon request
Laser Lifetime > 10,000 hours
Detectors 30 detector channels for multi-angle detection
Detector type Multi-element photodiode array for mobility measurements; Single photon counting module for QELS option
Instrument Options Embedded Quasi-Elastic Light Scattering (QELS)
Cell Options Reusable PEEK flow cell with optical quality windows for aqueous and organic solventsDisposable COC* cell for aqueous and polar organic solvents
Flow Cell Volume 170 μL, excluding tubing
Temperature Range 4 – 70ºC
Electrodes (Replaceable) Platinum-coated electrodes
Molar Mass Range < 5×107 g/mol (Daltons) (dependent on molecular shape model
Size Range 0.2 to 5000 nm, hydrodynamic radius (limited by particle sedimentation, this is typical)
Signal Processing Proprietary demodulation algorithm for efficient optical phase detection
Inputs/Outputs Alarm in, alarm retransmit, and remote start contact closure
Ionic Strength Range 0 – 50 mS/cm (4 times the conductivity of physiological saline)
Mobility Range No practical limit
Mobility Size Range 1 nm – 1 μm (depending on sample)
Mobility Sensitivity 1 mg/mL Lysozyme †
Communications Ethernet interface
Front Panel Display 162.5mm 16-bit high resolution LCD display with Graphical User Interface
Power 200 W typical, 400 W maximum
AC Voltage 90 – 250V @ 50 – 60 Hz, universal power input
Dimensions 59 cm (L) x 36 cm (W) x 21 cm (H); 23″ x 14″ x 8″
Weight 19 kg (41 lbs.)